Publications in Peer Reviewed Journals and Proceedings

Conference Lectures and Presentations

Patents


Publications in Peer Reviewed Journals and Proceedings


Since 1999, the research group comprising Quantum Dental Technologies has published over 30 articles and abstracts in peer-reviewed dental and medical journals. They have also presented their findings at over 20 international conferences and have two patents on the technology used in the Canary. A full list of those articles, presentations and patents is below, as are PDFs of some of the articles.

  1. Photothermal imaging moves forward in clinical trials by Kathy Kincad. DrBicuspid.com, March 4, 2011.
    View the Article in Adobe PDF Format
  2. Hellen A., Mandelis A., Finer Y., and Amaechi B.T. Quantitative evaluation of simulated human enamel caries kinetics using Photothermal Radiometry and Modulated Luminescence. Accepted for publication. J Biomed Opt, 2011
  3. Hellen A., Matvienko, A., Mandelis A., Finer Y., and Amaechi B.T. Optothermophysical properties of demineralized human dental enamel determined using photothermally generated diffuse photon density and thermal-wave fields. Appl Opt 49(36), 6938-6951 (2010).
    View the Article in Adobe PDF Format
  4. Jeon R. J., Sivagurunathan K., Garcia J., Matvienko A., Mandelis, A., Abrams S., Dental Diagnostic Clinical Instrument ("Canary") Development Using Photothermal Radiometry and Modulated Luminescence, Proc. 15 Int. Conf. Photoacoustic Photothermal Phenomena (15-ICPPP), July 19 - 23 2009, Leuven, Belgium, Journal of Physics: Conference Series (In press; accepted October 2009).
    View the Article in Adobe PDF Format
  5. (Invited) Matvienko A., Mandelis A., Jeon R. J., Abrams S. H., Theoretical analysis of coupled diffuse-photon-density and thermal-wave field depth profiles photothermally generated in layered turbid dental structures, Special Issue on Applied Biophysics; J. Appl. Phys. 105, 102022 (15 pages) (May 15, 2009). Paper selected for inclusion in Virtual Journal of Biological Physics Research (vjbo.osa.org), 17 (11), June 1, 2009. Section: Mulitcellular Phenomena.
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  6. Matvienko A., Mandelis A., Abrams S. H., Robust multi-parameter evaluation method of optical and thermal properties of a layered tissue structure using photothermal radiometry, Appl. Opt. 48 (17), 3193 - 3204 (June 2009). Paper selected for inclusion in Virtual Journal for Biomedical Optics (VJBO) (vjbo.osa.org), 4 (8), July 30, 2009. Section: Dentistry.
    View the Article in Adobe PDF Format
  7. Matvienko, A. Mandelis, A., Hellen, A., Jeon, R. J., Abrams S. H., Amaechi, B., Quantitative Analysis of Incipient Mineral Loss in Hard Tissues, (SPIE BiOS, San Jose, USA, January 2009), Proc. SPIE BiOS Vol. 7166 (12), 71660C1 - 12 (April 2009).
    View the Article in Adobe PDF Format
  8. Matvienko A., Mandelis A., Jeon R. J., Abrams S. H., Theoretical analysis of coupled diffuse-photon-density and thermal-wave field depth profiles photothermally generated in layered turbid dental structures, Journal of Applied Physics, Special Issue on Applied Biophysics, 2008, invited article, submitted.
  9. Jeon R. J., Hellen A., Matvienko A., Mandelis A., Abrams S. H., Amaechi B. T., In vitro Detection and Quantification of Enamel and Root Caries Using Infrared Photothermal Radiometry and Modulated Luminescence, Journal of Biomedical Optics 13(3), 048803, 2008.
    View the Article in Adobe PDF Format
  10. Mandelis A., Matvienko A., Abrams S. H., Theoretical Analysis of Dental Demineralization using Photothermal Radiometry, (SPIE BiOS, San Jose, USA, January 2008), Proc. SPIE Vol. 6856, (2008), 68560W.
    View the Article in Adobe PDF Format
  11. Jeon R. J., Hellen A., Matvienko A., Mandelis A., Abrams S. H., Amaechi B. T., Experimental Investigation of Demineralization and Remineralization of Human Teeth Using Infrared Photothermal Radiometry and Modulated Luminescence, (SPIE BiOS, San Jose, USA, January 2008), Proc. SPIE Vol. 6856, (2008), 68560B.
  12. Jeon, R. J., Matvienko, A., Mandelis, A., Abrams, S. H., Amaechi, B. T., Kulkarni, G., Interproximal Dental Caries Detection using Photothermal Radiometry (PTR) and Modulated Luminescence (LUM), European Physical Journal, Special Topics, 2008, 153; 467 - 469
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  13. Matvienko, A., Jeon, J., Mandelis, A., Arvizu, G., Gomez, A. E., Abrams, S. H., Dental Biothermophtonics: A Quantitative Photothermal Analysis of Early Dental Demineralization, (Proc. 14th Photoacoustic & Photothermal Phenomena Conference, Cairo, Egypt, January 2007), European Physical Journal, Special Topics, 2008, 153; 463 - 465
    View the Article in Adobe PDF Format
  14. Mandelis, A., Jeon, R., Matvienko, A., Abrams, S. H., Amaechi, B., Dental Biothermophotonics: How Photothermal Methods are Winning the Race with X-Rays for Dental Caries Diagnostic Needs of Clinical Dentistry, (Proc. 14th Photoacoustic & Photothermal Phenomena Conference, Cairo, Egypt, January 2007), European Physical Journal, Special Topics, 2008, 153; 449 - 454
    View the Article in Adobe PDF Format
  15. Jeon R.J., Matvienko A., Mandelis A., Abrams S.H., Amaechi B.T, Kulkarni G., Detection of interproximal demineralized lesions on human teeth in vitro using frequency-domain infrared photothermal radiometry and modulated luminescence, J. Bio. Optics, 12(3) 034028, 2007(selected for Virtual Journal of Biological Physics Research, July 1, 2007).
    View the Article in Adobe PDF Format
  16. Matvienko A., Jeon R. J., Mandelis A., Abrams S. H., Amaechi B. T., Photothermal Detection of Incipient Dental Caries: Experiment and Modeling, (SPIE Optics East, Boston, USA, September 2007), Proc. SPIE Vol. 6759, 67590J, 2007.
    View the Article in Adobe PDF Format
  17. Matvienko, A., Jeon, R. J. Mandelis, A., Abrams, S. H., Kulkarni, G. V., Detection of Incipient Caries with Dental Photothermal Radiometry: Experiments and Theoretical Modeling, ORCA Abstract # 131, Caries Research 2006, 40:348
  18. Jeon, R. J. Matvienko, A., Mandelis, A., Abrams, S. H., Amaechi, B. T., Kulkarni, G. V., Interproximal Caries Detection Using Frequency-Domain Infrared Photothermal Radiometry, ORCA Abstract # 132, Caries Research 2006, 40:348
  19. Abrams, S., Scarlett, M., and Trost, L., Focus on Dental Caries Management? Beyond Extension for Prevention to Minimal Intervention, Oral Health Magazine, March 2006, pp. 69-76.
    View the Article in Adobe PDF Format
  20. Jeon, R. J., Han, C., Mandelis, A., Sanchez, V., Abrams, S. H., Dental Depth Profilometric Diagnosis of Pit & Fissure Caries using Frequency-Domain Infrared Photothermal Radiometry and Modulated Laser Luminescence, Early Detection of Caries III Proceedings of the Sixth Indiana Conference Indiana University School of Dentistry, pages 49 - 67, Stookey, G., editor, 2003
  21. Jeon R. J., Phan T. D. T., Wu A., Kulkarni G., Abrams S. H., and Mandelis A., Photothermal radiometric quantitative detection of the different degrees of demineralization of dental enamel by acid etching, J. Physique IV France, 2005 125, 721 - 723.
    View the Article in Adobe PDF Format
  22. Jeon, RJ., Mandelis, Sanchez, V., and Abrams, SH., Dental depth profilometric diagnosis of pit & fissure caries using frequency-domain infrared photothermal radiometry and modulated laser luminescence, Proc. 13th Int. Conf. Photoacoustic & Photothermal Phenomena, July 5 - 8, 2004, J. Physique IV France, 2005: 125: 741 - 744
  23. Phan, T. D. T., Mandelis, A., Abrams, S. H., Jeon, R. J., el-Mowafy, A., Kulkarni, G. V., Laser Photothermal Radiometry for the Detection of Early Enamel Demineralization, Abstract # 0697, IADR, 2005
  24. Jeon, R. J., Han, C., Mandelis, A., Sanchez, V., Abrams, S. H., Diagnosis of Pit & Fissure Caries using Frequency-Domain Infrared Photothermal Radiometry and Modulated Laser Luminescence, Caries Research 2004 Volume 38, pages 497- 513
    View the Article in Adobe PDF Format
  25. R. Jeon, A. Mandelis and S. Abrams, Dental depth profilometric diagnosis of pit and fissure caries using frequency-domain infrared photothermal radiometry and modulated luminescence, SPIE Vol. 5320, Photons plus Ultrasound: Imaging and Sensing (A. A. Oraevsky and L. V. Wang, Eds., Bellingham WA 2004, pp. 29 39
  26. Jeon, R. J., Han, C., Mandelis, A., Sanchez, V., Abrams, S. H., Non-intrusive, Non-contacting Frequency-Domain Photothermal Radiometry and Luminescence Depth Profilometry of Carious and Artificial Sub-surface Lesions in Human Teeth, Journal of Biomedical Optics 2004, July - August ,9, # 4, 809 - 819.
    View the Article in Adobe PDF Format
  27. Jeon, R. J., Mandelis, A., Sanchez, V., Abrams, S. H., Dental Depth Profilometric Diagnosis of Pit & Fissure Caries using Frequency-Domain Infrared Photothermal Radiometry and Modulated Laser Luminescence, SPIE Meeting BIOS 2004, January Poster Proceedings.
  28. Trost, L., Scarlett, M., and Abrams, S., Focus on Dental Caries Management ? - Part 2 of 3, Woman Dentist Journal, January 2004, pp. 24-33
    View the Article in Adobe PDF Format
  29. Trost, L., Scarlett, M., and Abrams, S., Focus on Dental Caries Management ? - Part 1 of 3, Woman Dentist Journal, November/December 2003.
    View the Article in Adobe PDF Format
  30. Jeon, R. J., Han, C., Mandelis, A., Sanchez, V., Abrams, S. H., Dental Depth Profilometric Diagnosis of Pit & Fissure Caries using Frequency-Domain Infrared Photothermal Radiometry and Modulated Laser Luminescence, Proceedings of the Third Indiana University Conference on Early Caries Detection, 2003, 49-67.
  31. Jeon, R. J., Mandelis, A., Abrams, S. H., Depth profilometric case studies in caries diagnostics of human teeth using modulated laser radiometry and luminescence, Review of Scientific Instruments, 2003, January, Volume 74 # 1, pages 380 - 383
  32. Nicolaides, L., Feng, C., Mandelis, A., Abrams, S. H., Quantitative Dental Measurements by use of simultaneous Frequency - Domain Laser Infrared Radiometry and Luminescence, Applied Optics, 2002, February, Volume 41, (4), pages 768 -777
  33. Nicolaides, L., Feng, C., Mandelis, A., Abrams, S. H., Dental Dynamic Diagnostics using Simultaneous Frequency-domain PTR and Laser Luminescence, Anal Sci. (J. Japan Soc. Anal. Chem.), 2001, Volume 17, (Special Issue), s330 - s333
  34. Nicolaides, L., Garcia, J., Mandelis A., Abrams, S.H, Dental Depth Profilometry using simultaneous Frequency-Domain Infrared Photothermal Radiometry and Laser Luminescence for the Diagnosis of Dental Caries, accepted for publication in Biomedical Optoacoustics, Proc. SPIE BIOS Meeting, San Jose, CA, Jan. 20 -26, 2001 (A. A. Oraevsky, Ed., SPIE, Bellingham, WA, 2001) (SPIE Proceedings are Editor refereed).
    View the Article in Adobe PDF Format
  35. Nicolaides, L, Mandelis, A., Abrams, S. H., Novel Dental Dynamic Depth Profilometric Imaging using Simultaneous Frequency Domain Infrared Photothermal Radiometry and Laser Luminescence, Journal of Biomedical Optics, 2000, January, Volume 5, # 1, pages 31 - 39.
    View the Article in Adobe PDF Format
  36. Nicolaides, L., Garcia, J. Mandelis, A., Abrams, S., Dental Depth Profilometry using Simultaneous Frequency-Domain Infrared Photothermal Radiometery and Laser Luminescence for the Diagnosis of Dental Caries, in Progress in Biomedical Optics and Imaging, (Rechman, P., Fried, D., Henning, T., editors), Proc. SPIE 2000, Volume, 4249, pages 79- 86
  37. Mandelis, A., Nicolaides, L., Feng, C., Abrams, S H., Novel dental depth profilometric imaging using simultaneous frequency-domain infrared photothermal radiometry and laser luminescence, in Biomedical Optoacoustics, (Oraevsky, A, editor), Proc. SPIE 2000, Volume, 3916, pages 130- 137
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Conference Lectures and Presentations


Over the last nine years, our group has made and been invited to speak at 29 conferences world wide on early caries detection and also the science behind our device.

  1. Sivagurunathan, K., Abrams, S.A., Jeon, R., Garcia, J., Mandelis, A., Amaechi, B.T., and Finer, Y., PTR-LUM ("The Canary System™") Clinical Trial Results for Caries Detection, Presentation at IADR, July 2010.
    View the Abstract in Adobe PDF Format
  2. Hellen, A. Mandelis, Y. Finer and B.T. Amaechi. "Quantitative Examination of Demineralized and Remineralized Dental Lesions Using Photothermal Radiometry and Modulated Luminescence", Session R1-7-5: Lasers and Ultrasound. Canadian Association of Physicists Congress, Toronto, ON, Canada, June 2010.
  3. Sivagurunathan, K., Abrams, S.H., Garcia, J., Mandelis, A., Amaechi, B.T., Finer, Y., Using PTR-LUM ("The Canary System™") for in-vivo detection of dental caries: clinical trial results, Abstract at ORCA, July 2010.
    View the Abstract in Adobe PDF Format
  4. Hellen, A., Mandelis, A., Finer Y., Photothermal Radiometry and Modulated Luminescence Examination of Demineralized and Remineralized Lesions, Proc. 15 Int. Conf. Photoacoustic Photothermal Phenomena (15-ICPPP), July 19 – 23 2009, Leuven, Belgium, Journal of Physics: Conference Series (In press; accepted October 2009).
  5. (Invited) Hellen, A., Mandelis, A., Finer, Y., Amaechi, B., Quantitative examination of demineralized and remineralized dental lesions using photothermal radiometry and modulated luminescence, SPIE BiOS Proc. SPIE 7548, 75484G (2010).
  6. Matvienko, A., Hellen, A., Jeon, R. J., Mandelis, A., Abrams, S.H., Amaechi, B.T., Photothermal Evaluation of Demineralization Kinetics of Human Enamel, Abstract # 26: ORCA Congress, July 2009.
    View the Abstract in Adobe PDF Format
  7. Hellen, A., Jeon, R., Matvienko, A., Mandelis, A., Abrams S.H., Amaechi, B.T., Erosion Lesion Detection using Photothermal Radiometry and Modulated Luminescence, Abstract # 70, Oral session #17: Conventional and Alternate Imaging Modalities in Dentistry, IADR, 2009.
  8. Mandelis, A., Jeon, R., Hellen, A., Matvienko, A., Abrams S., Amaechi, B., Investigation of Demineralization and Remineralization of Human Teeth Using Infrared Photothermal Radiometry and Modulated Luminescence, Canadian Association of Physicists Annual Congress, June 8 - 11, 2008; Paper TU-A5-1.
  9. Mandelis A., Matvienko A., Abrams S. H., Theoretical Analysis of Dental Demineralization using Photothermal Radiometry, SPIE BiOS 2008, San Jose, USA, January 19-24, 2008. Proc. SPIE Vol. 6856 (2008).
  10. Jeon R. J., Hellen A., Matvienko A., Mandelis A., Abrams S. H., Amaechi B. T., Experimental Investigation of Demineralization and Remineralization of Human Teeth Using Infrared Photothermal Radiometry and Modulated Luminescence, SPIE BiOS 2008, San Jose, USA, January 19-24, 2008. Proc. SPIE Vol. 6856 (2008).
  11. Matvienko A., Jeon R. J., Mandelis A., Abrams S. H., Amaechi B. T., Photothermal Detection of Incipient Dental Caries: Experiment and Modeling, SPIE Optics East 2007, Boston, USA, September 9-12, 2007. Proc. SPIE Vol. 6759 (2007), 67590J.
  12. Jeon R.J., Hellen A., Matvienko A., Mandelis A., Abrams S.H., Amaechi B.T., Detection of Demineralized-Remineralized Lesions on Root and Enamel of Human Teeth in vitro Using Infrared Photothermal Radiometry and Modulated Luminescence, 54th Annual ORCA Congress, Helsingör, Denmark, July 4-7, 2007.
  13. Matvienko A., Jeon R.J., Mandelis A., Abrams S.H., Amaechi B.T., Monitoring of early enamel demineralization on human teeth using photothermal radiometry: experiment and theory, 54th Annual ORCA Congress, Helsingör, Denmark, July 4-7, 2007.
  14. Matvienko A., Jeon R., Garcia J., Mandelis A., Abrams S., Dental Demineralization Detection: Experiment and Theory, OCE Discovery 2007:TO NEXT, Toronto, Canada, May 1, 2007.
  15. Matvienko A., Jeon R.J., Mandelis A., Abrams S.H., Dental Photothermal Radiometry: Theoretical Analysis, APS meeting, Denver, CO, March 5-9, 2007.
  16. Matvienko A., Jeon R.J., Mandelis A., Arvizu G., Esteban Gomez A., Abrams S.H., Amaechi B.T., Dental Biothermophotonics: A quantitative photothermal analysis of early dental demineralization, 14th Photoacoustic & Photothermal Phenomena Conference, Cairo,  Egypt, January 6-9, 2007.
  17. Jeon R.J., Matvienko A., Mandelis A., Abrams S.H., Amaechi B.T., Kulkarni G., Interproximal Dental Caries Detection using Photothermal Radiometry (PTR) and Modulated Luminescence (LUM), 14th Photoacoustic & Photothermal Phenomena Conference, Cairo, Egypt, January 6-9, 2007.
  18. Matvienko A., Jeon R.J., Mandelis A., Abrams S.H., Kulkarni G., Characterization of dental demineralization using a biothermophotonic technique, 16th Symposium on Thermophysical Properties, Boulder, USA, July 2006. Highlighted in Radiative Properties and Radiometric Techniques for Property Measurements by Z. Zhang, ASME International Mechanical Engineering Congress and Exposition, Illinois, USA, November 2006.
  19. Jeon R., Matvienko A., Mandelis A., Abrams S., Amaechi B., Kulkarni G., Interproximal caries detection using frequency-domain infrared photothermal radiometry, 53rd Annual ORCA Congress, Glasgow, UK, July 2006.
  20. Matvienko A., Jeon R., Mandelis A., Abrams S., Kulkarni G., Detection of enamel demineralization with dental photothermal radiometry: experiments and theoretical modeling, 53rd Annual ORCA Congress, Glasgow, UK, July 2006.
  21. Matvienko A., Jeon R., Mandelis A., Abrams S., Biothermophotonic method for the diagnosis of incipient dental caries, Discovery 2006 Conference - Ontario Centres of Excellence, Toronto, Canada, February 2006. Top award (student poster competition).
  22. Matvienko A., Jeon R., Mandelis A., Abrams S., Kulkarni G., Detection of artificial surface and subsurface dental caries mineral loss using laser photothermal radiometry, 52nd Annual ORCA Congress, Indianapolis, USA, July 2005.
  23. Jeon, R. J., Mandelis, A., Sanchez, V., Abrams, S. H., Dental Depth Profilometric Diagnosis of Pit & Fissure Caries using Frequency-Domain Infrared Photothermal Radiometry and Modulated Laser Luminescence, SPIE Meeting BIOS 2004, January Poster Proceedings.
  24. Mandelis, A., Dental Depth Profilometric Diagnosis of Pit and Fissure Caries unisng Frequency-Domain Infrared Photothermal Radiometry and Modulated Laser Luminescence, Academic Center for Dental Sciences, Free University of Amsterdam, Amsterdam, the Netherlands; April 20, 2004.
  25. Mandlelis, A., Biomedical photothermal and photothermoacoustic diagnostics for cancer imaging and dental caries prevention, Dept. of Physics, Festkoerperspektroskopie III, Ruhr Univ. Bochum, Germany; January 23, 2004.
  26. Mandelis, A., Advances in Photothermal Radiometry and Luminescence Diagnostics of Natural Carious and Artificial Sub-surface Lesions in Human Teeth, Gordon Research Conference on Photoacoustic and Photothermal Phenomena, Colby-Sawyer College, New London, NH, June 8-13 (2003).
  27. Abrams, S., Frequency Domain Infrared Photothermal Radiometry and Modulated Laser Luminescence, The Indiana Conference, School of Dentistry, Indiana University - Purdue University, Indianapolis, May 21 - 23 (2003).
  28. Mandelis, A., Progress in Theoretical, Experimental and Computational Investigations in Turbid Tissue Phantoms and Human Teeth using Laser Infrared Photothermal Radiometry, ThermoSense XXIV, Orlando, FL, 1-5 April 2002 (paper 4710-42).
  29. Mandelis, A. Nicolaides, L. Feng, C., Abrams S.H., Novel Dental Depth Profilometric Imaging using Simultaneous Frequency-Domain Infrared Photothermal Radiometry and Laser Luminescence, Proc. SPIE BiOS 2000 Conference, San Jose, CA, January 2000 (A. A. Oraevsky, Ed.) Vol. 3916 (2000), pp. 130-137. (SPIE Proceedings are Editor refereed).
  30. Nicolaides, L., Garcia, J., Mandelis A., Abrams, S. H., Dental Depth Profilometry using Simultaneous Frequency-Domain Infrared Photothermal Radiometry and Laser Luminescence for the Diagnostics of Dental Caries, Proc. SPIE BiOS 2001 Conference, San Jose, CA, January 2001, (P. Rechmann, D. Fried and T. Hennig, Eds.) Vol. 4249 (2001) pp. 79-86. (SPIE Proceedings are Editor refereed).
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Patents


  1. Mandelis, A, Abrams, S, Method of Assessing Oral Health Risk, US Patent # 61/202,499
    March 10, 2010
  2. Mandelis, A, Abrams, S, Method of Assessing Oral Health Risk, PCT Patent # 61/202,499 March 10, 2010
  3. Mandelis, A., Abrams, S, Nicolaides, L., Garcia, J. A., Method and Apparatus for Detection of Defects in Teeth, Canadian Patent # 2,314,691 accepted July 28, 2000, U. S. Patent # 6,584,341 accepted June 24, 2003.
  4. Mandelis, A, Abrams, S, Jeon, J-S., Kulkarni, K., Mativenko, A., Method and Apparatus Using Infrared Photothermal Radiometry (PTR) and Modulated Laser Luminescence (LUM) for Diagnostics of Defects in Teeth, US Provisional Patent # 11/488,194,Worldwide Patent application PCT/CA2006/001171.
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